It has such a profound effect on our brains that the drug has been touted as a treatment for certain mental-health conditions, including PTSD and depression.
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Scientists have found that LSD molecules bind to serotonin receptors in the brain, altering the brain’s chemical pathways. In turn, this can lead to hallucinations and intense emotions.
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But scientists are still studying exactly how the mechanism works. One team of researchers just discovered a new clue.
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Using X-rays to determine the LSD molecule’s crystal structure, the scientists discovered how exactly it binds to the serotonin receptor.
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It all comes down to one amino acid, a single building block of the protein that LSD binds to.
As LSD settles into a “pocket” in the serotonin receptor, the amino acid shifts position, allowing the pocket to expand.
The LSD molecule also creates a “lid” over the serotonin receptor, which is why trips can last hours.
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Some researchers have advocated for LSD as a treatment for conditions like cluster headaches, anxiety, and depression since the mid-19th century.
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But to fully understand its therapeutic potential, first scientists have to know every intimate detail about how the molecule affects our brains.
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With this new finding, scientists are getting closer to harnessing LSD’s powerful effects to potentially help people in need.